A spokeswoman said consultation on the first round of cuts was set to begin in early May.
However, she said buyers could be affected by a second round of 500 job losses in the next financial year.
“It is unlikely the first tranche will include the buying units. We will be looking at processes and ways we can be more efficient in the way we do things,” she added.
Jobs will be shed in the London head office and divisional centres in Chester, Manchester and Stockley Park.
Marks and Spencer plans to save around £25m a year through the job cuts. Some will be lost through natural wastage and the rest through redundancies.