Part of their anger is being directed at the independent grocers' lobby group, RGDATA, which brought the appeal on behalf of local retailers.
It objected both to the location and design of the store, which it claimed would not be in keeping with Cashel's status as a 'heritage town'. An Bord Pleanala agreed and upheld the appeal.
Planning permission for the store, to be built on the outskirts of the town, had been granted by South Tipperary County Council and unanimously endorsed by local councillors. "We're shocked and angered by the decision," said Dan Dillon, who recently completed his term as town mayor.
"This was a vote of confidence in Cashel and its future by Tesco. It would have created 80 new jobs and stemmed the loss of business to supermarkets in neighbouring towns."
He appealed to Tesco to submit a revised planning application. Tesco declined to comment.
Discount chain Aldi has also been refused permission for a store on the edge of Tipperary Town.