Over 150 wines have been selected from independent and national chains including Tesco, Sainsbury and First Quench to take part in Wine Relief 2003.
All the companies have agreed to donate £1 from each bottle sold and the promotion will be flagged up with bottle colarettes featuring Tony Blackburn.
Comic Relief chief executive Kevin Cahill said: "During the last Red Nose Day campaign in 2001, Wine Relief raised an incredible £350,000, with retailers enjoying a substantial uplift (up to 165%) in the sale of highlighted wines during a two-week sales period." The promotion will kick off on February 7 and run until March 14.
Comic Relief is also running a competition to encourage consumers to vote on their favourite wine. The charity will get a cut of the cost of text messages sent to voting lines for either red or white wine aimed at discovering the nation's favourite colour.