The changes are intended to communicate the Irish "personality" of the ale with an emerald green can and Caffrey's Celtic symbol.
Multipacks of the beer will feature an image of a freshly poured pint.
Coors said the redesign was intended to position the beer as the "only modern, premium widget ale".
Coors director of marketing for premium beers, David Preston, said: "It is important that Caffrey's keeps its image.
"The redesign reaffirms Caffrey's positioning as a premium beer brand with a much younger age profile than other widget ales."