The company said full-year profit would be at the lower end of City expectations and that initiatives to turnaround the business would cost £55m of which £30m relates to write-offs.
Some 700 jobs will go at Wellbeing with 12 outlets offering health and beauty services closed at a cost of £34m including £16m in asset write-offs.
The company is to close its loss-making European operations and streamline the supply chain for its business in the Far East at a cost of £9m.
Fourth quarter like-for-like sales at Boots the Chemist rose 3.6% but the late Easter will hit growth in the quarter by 0.4%.
It expects second half like-for-like sales to be up 5.9% and BHI sales growth of about 13%.
Full-year results are scheduled for June 5.