Camelot commercial and operations director Phil Smith is to leave the lottery operator by mutual consent.
The move comes after Camelot chief executive Dianne Thompson announced last month that she intended to stay at the company until at least 2012, should it be successful in winning a third licence to operate the National Lottery from 2009 to 2019.
Smith, who is currently on gardening leave, joined Camelot as commercial director in January 2002, having held marketing roles with Somerfield and Kraft Foods. He effectively took control of the day-to-day running of Camelot in May 2005, while Thompson put together the license bid, which was submitted to the National Lottery Commission on 9 February.
A spokeswoman for Camelot said it would not be considering a replacement until it found out if its bid was successful. Camelot faces only one competitor for the bid, Indian lottery operator Sugal & Damani. The decision will be made this summer.