Scratchcards that are going into stores from today will give players the chance to win one of 400 holidays from Thomas Cook, worth £5,000 each.
In addition there are instant cash prizes, ranging from £1 to £2,500.
The game costs £1 to play and the overall odds of winning a prize are 1 in 5.26.
Camelot will support the Holiday Bonanza with a TV advertising campaign being aired for two weeks from January 20 and for two weeks from February 10.
The campaign is the first in a new wave of Camelot advertising featuring good causes supported by the lottery.