Tesco is the latest UK operator to leave the booze cruise capital after the exit of Sainsbury's and Oddbins earlier this year. They have all closed due to the tough market conditions caused by cheaper booze at home and the pound's slump against the euro.
A spokesman for Tesco said: "We worked closely with local management and unions to support staff during this difficult time."
The website for the outlet www.tesco.com/vinplus is being redirected to Tesco's wine by the case website at www.tesco/wine.
In March, Oddbins boss Simon Baile predicted a "complete revolution" in the number and size of stores in Calais due to the tough trading conditions.