InBev said that Pedrick, who became UK and Ireland president in July last year, was stepping down following a recent restructure that had resulted in the creation of a single commercial team.
Pedrick is replaced by Richard Evans, who is promoted from the role of vice president of brands.
Evans, who is taking up his new role on May 5, has been based at InBev's global headquarters in Leuven, Belgium, since June 2003.
He joined the company from Procter & Gamble in 1994 and has since held the roles of marketing manager for the Heineken brand, director of customer marketing, brands director, vice president of commercial strategy and vice president of brands.
Stefan Descheemaeker, president, western European zone at InBev, said: "I believe that Richard's understanding and experience of the UK market and his marketing and commercial skills, combined with the broader perspective and exposure to different approaches he has gained in his global roles, will equip him particularly well to lead the future growth of InBev UK."
He added: "Colin will be remembered by all who worked closely with him for his honest, no-nonsense approach and his incredible passion for driving the business forward."